![]() ![]() Anemia is driven on by the direct reduction in red blood cell survival mediated by pro-inflammatory cytokines. Other hypothesized mechanisms for iron deficiency include impaired erythropoietin production and release from the kidney and elevated hepcidin levels in the liver. Moreover, suggests that chronic inflammation due to the aberrant activation of pro-inflammatory cytokines (interleukin-6, 8, tumor necrosis factor-alpha, and interferon-gamma), are central to the development of IDA. ![]() Data drawn from each study was critically evaluated, and personal viewpoints were made from the results.Īccording to the evidence summarized in this review, shows T2DM patients have an increased risk of developing IDA. About 33 studies were retrieved, however, only 15 were deemed relevant to this review. Two independent researchers searched the literature on MEDLINE. This review sought to highlight the interlink between T2DM and the development of iron deficiency anemia. However, the exact mechanisms have not been properly documented. Type 2 diabetes mellitus (T2DM) is implicated in developing various comorbidities and complications, including iron deficiency anemia (IDA). This is contradictory to transfusion guidelines for chronic anemia which address the importance of symptoms. Age of the patient is more important in the decision-making process to younger gastroenterologists (OR −2.9, 95% CI −5.3 to −0.5).Ībsolute hemoglobin level is the most important factor to transfusion decision-making. A hemoglobin level >9.6 g/dL is an inflection point, where gastroenterologists would not prescribe transfusions. Absolute hemoglobin level was the most important incentive of transfusion, accounting for 42% of decision-making, followed by age (15%), hemoglobin stability (12%), anemia-related symptoms (10%), and cardiovascular comorbidities (10%). ![]() ![]() Predictors of transfusion preferences were assessed by multivariable regression.ġ13 gastroenterologists completed the survey (response rate = 29% mean age = 47 years 24% women). The survey included seven patient attributes: hemoglobin levels, hemoglobin stability, age, iron indices, the presence of anemia-related symptoms, cardiovascular comorbidities, and the number of transfusions in the past half year. The aim is to identify preferences and predictors of transfusion decision-making in chronic anemia.īetween February and April of 2015, a computerized adaptive choice-based conjoint survey was administered to gastroenterologists in the Netherlands. The hypothesis is that decision-making for transfusion varies considerably among gastroenterologists. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
February 2023
Categories |